dotinurad   Click here for help

GtoPdb Ligand ID: 11389

Synonyms: FYU-981 | FYU981 | Urece®
Approved drug PDB Ligand
dotinurad is an approved drug (Japan (2018))
Compound class: Synthetic organic
Comment: Dotinurad, a novel selective urate reabsorption inhibitor (SURI), that acts on the URAT-1 transporter.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 2
Topological polar surface area 83.06
Molecular weight 356.96
XLogP 2.86
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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Canonical SMILES O=C(N1CS(=O)(=O)c2c1cccc2)c1cc(Cl)c(c(c1)Cl)O
Isomeric SMILES O=C(N1CS(=O)(=O)c2c1cccc2)c1cc(Cl)c(c(c1)Cl)O
InChI InChI=1S/C14H9Cl2NO4S/c15-9-5-8(6-10(16)13(9)18)14(19)17-7-22(20,21)12-4-2-1-3-11(12)17/h1-6,18H,7H2
InChI Key VOFLAIHEELWYGO-UHFFFAOYSA-N
References
1. Taniguchi T, Ashizawa N, Matsumoto K, Saito R, Motoki K, Sakai M, Chikamatsu N, Hagihara C, Hashiba M, Iwanaga T. (2019)
Pharmacological Evaluation of Dotinurad, a Selective Urate Reabsorption Inhibitor.
J Pharmacol Exp Ther, 371 (1): 162-170. [PMID:31371478]