dotinurad   Click here for help

GtoPdb Ligand ID: 11389

Synonyms: FYU-981 | FYU981 | Urece®
Approved drug PDB Ligand
dotinurad is an approved drug (Japan (2018))
Compound class: Synthetic organic
Comment: Dotinurad, a novel selective urate reabsorption inhibitor (SURI), that acts on the URAT-1 transporter.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 2
Topological polar surface area 83.06
Molecular weight 356.96
XLogP 2.86
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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Canonical SMILES O=C(N1CS(=O)(=O)c2c1cccc2)c1cc(Cl)c(c(c1)Cl)O
Isomeric SMILES O=C(N1CS(=O)(=O)c2c1cccc2)c1cc(Cl)c(c(c1)Cl)O
InChI InChI=1S/C14H9Cl2NO4S/c15-9-5-8(6-10(16)13(9)18)14(19)17-7-22(20,21)12-4-2-1-3-11(12)17/h1-6,18H,7H2
InChI Key VOFLAIHEELWYGO-UHFFFAOYSA-N
Selectivity at transporters
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
Urate anion exchanger 1 Primary target of this compound Hs Inhibitor Inhibition 6.4 pIC50 - 1
pIC50 6.4 (IC50 4x10-7 M) [1]