[125I]HPP-HOE140   Click here for help

GtoPdb Ligand ID: 11436

Synonyms: [125I]-3-4-hydroxyphenyl-propionyl-d-Arg0-[Hyp3,Thi5,d-Tic7,Oic8]bradykinin [2]
 Ligand is labelled  Ligand is radioactive
Compound class: Peptide or derivative
Comment: This is a radio-labelled antagonist probe for B2 receptors [1-3]. It is a derivative of icatibant (HOE140).
References
1. de Sousa Buck H, Ongali B, Thibault G, Lindsey CJ, Couture R. (2002)
Autoradiographic detection of kinin receptors in the human medulla of control, hypertensive, and diabetic donors.
Can J Physiol Pharmacol, 80 (4): 249-57. [PMID:12025957]
2. Murone C, Perich RB, Schlawe I, Chai SY, Casley D, MacGregor DP, Müller-Esterl W, Mendelsohn FA. (1996)
Characterization and localization of bradykinin B2 receptors in the guinea-pig using a radioiodinated HOE140 analogue.
Eur J Pharmacol, 306 (1-3): 237-47. [PMID:8813637]
3. Ongali B, Hellal F, Rodi D, Plotkine M, Marchand-Verrecchia C, Pruneau D, Couture R. (2006)
Autoradiographic analysis of mouse brain kinin B1 and B2 receptors after closed head trauma and ability of Anatibant mesylate to cross the blood-brain barrier.
J Neurotrauma, 23 (5): 696-707. [PMID:16689671]