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Synonyms: compound 10g [PMID: 30655942]
Compound class: Synthetic organic
Comment: Compound 10g is a potent Kv7.4 and Kv7.5 channel agonist . It does not potentiate activity of Kv7.1 or Kv7.2 channels.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Wang L, Qiao GH, Hu HN, Gao ZB, Nan FJ. (2019)
Discovery of Novel Retigabine Derivatives as Potent KCNQ4 and KCNQ5 Channel Agonists with Improved Specificity.
ACS Med Chem Lett, 10 (1): 27-33. [PMID:30655942]