Synonyms: ARV-110 | ARV110 | compound 406 [WO2018071606A1]
Compound class:
Synthetic organic
Comment: Bavdegalutamide (ARV110) is a bifunctional degarder class compound (PROTAC). One end of the molecule binds to the androgen receptor and the other binds to the cereblon E3 ligase and directs the AR for proteasome-mediated degradation [1]. It has clinical potential as an oral therapy for metastatic castration-resistant prostate cancer. PubChem CID 134414307 represents the molecule without specified stereo chemistry.
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References |
1. Crew AP, Hornberger KR, Snyder LB, Zimmermann K, Wang J, Berlin M, Crews CM, Dong H. (2018)
Compounds and methods for the targeted degradation of androgen receptor. Patent number: WO2018071606A1. Assignee: Arvinas Inc.. Priority date: 11/10/2016. Publication date: 19/04/2018. |