abrilumab   Click here for help

GtoPdb Ligand ID: 11531

Synonyms: AMG 181 | AMG-181 | MEDI-7183 | MEDI7183
Immunopharmacology Ligand
Compound class: Antibody
Comment: Abrilumab (AMG-181, MEDI-7183) is a fully human IgG2κ monoclonal antibody which selectively targets α4β7 integrin heterodimers [1] that was developed by MedImmune. It was designed for the treatment of inflammatory bowel diseases (ulcerative colitis [2], and Crohn's disease).
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1. Pan WJ, Hsu H, Rees WA, Lear SP, Lee F, Foltz IN, Rathanaswami P, Manchulenko K, Chan BM, Zhang M et al.. (2013)
Pharmacology of AMG 181, a human anti-α4 β7 antibody that specifically alters trafficking of gut-homing T cells.
Br J Pharmacol, 169 (1): 51-68. [PMID:23425116]
2. Sandborn WJ, Cyrille M, Hansen MB, Feagan BG, Loftus Jr EV, Rogler G, Vermeire S, Cruz ML, Yang J, Boedigheimer MJ et al.. (2019)
Efficacy and Safety of Abrilumab in a Randomized, Placebo-Controlled Trial for Moderate-to-Severe Ulcerative Colitis.
Gastroenterology, 156 (4): 946-957.e18. [PMID:30472236]