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Synonyms: ICI 199,441 | ICI199441 | ligand 1 [PMID: 8893842]
Compound class: Synthetic organic
Comment: ICI-199441 is a κ opioid receptor agonist .
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Chang AC, Cowan A, Takemori AE, Portoghese PS. (1996)
Aspartic acid conjugates of 2-(3,4-dichlorophenyl)-N-methyl-N-[(1S)-1(3-aminophenyl)-2-(1-pyrrolidi nyl) ethyl]acetamide: kappa opioid receptor agonists with limited access to the central nervous system.
J Med Chem, 39 (22): 4478-82. [PMID:8893842]
2. Kumar V, Guo D, Daubert JD, Cassel JA, DeHaven RN, Mansson E, DeHaven-Hudkins DL, Maycock AL. (2005)
Amino acid conjugates as kappa opioid receptor agonists.
Bioorg Med Chem Lett, 15 (5): 1279-82. [PMID:15713370]
3. Kumar V, Guo D, Marella M, Cassel JA, Dehaven RN, Daubert JD, Mansson E. (2008)
Use of receptor chimeras to identify small molecules with high affinity for the dynorphin A binding domain of the kappa opioid receptor.
Bioorg Med Chem Lett, 18 (12): 3667-71. [PMID:18487043]