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Abbreviated name: HMA
Compound class: Synthetic organic
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Heitman LH, Ye K, Oosterom J, Ijzerman AP. (2008)
Amiloride derivatives and a nonpeptidic antagonist bind at two distinct allosteric sites in the human gonadotropin-releasing hormone receptor.
Mol. Pharmacol., 73 (6): 1808-15. [PMID:18344315]
2. Leppik RA, Lazareno S, Mynett A, Birdsall NJ. (1998)
Characterization of the allosteric interactions between antagonists and amiloride analogues at the human alpha2A-adrenergic receptor.
Mol. Pharmacol., 53 (5): 916-25. [PMID:9584219]
3. Wilson AL, Womble SW, Prakash C, Cragoe Jr EJ, Blair IA, Limbird LE. (1992)
Novel amiloride analog allosterically modulates the alpha 2-adrenergic receptor but does not inhibit Na+/H+ exchange.
Mol. Pharmacol., 42 (2): 175-9. [PMID:1325028]