dorzagliatin   Click here for help

GtoPdb Ligand ID: 12124

Synonyms: HMS-5552 | HMS5552 | RO-5305552 | RO5305552 | Sinogliatin
Approved drug
dorzagliatin is an approved drug (China (2022))
Compound class: Synthetic organic
Comment: Dorzagliatin (HMS5552) is an allosteric glucokinase (GCK) activator [3,5], that targets both pancreatic and hepatic GCK, and is a 'full' activator that increases GCK's maximum velocity (Vmax) [7]. GCK activators are being developed as novel drugs for the treatment of type 2 diabetes mellitus (T2DM) [1-2,4].
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 7
Hydrogen bond donors 3
Rotatable bonds 11
Topological polar surface area 116.92
Molecular weight 462.17
XLogP 2.23
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES OC[C@@H](Cn1ccc(n1)NC(=O)[C@@H](N1CC(=CC1=O)Oc1ccccc1Cl)CC(C)C)O
Isomeric SMILES CC(C)C[C@@H](C(=O)Nc1nn(cc1)C[C@H](CO)O)N1CC(=CC1=O)Oc1ccccc1Cl
InChI InChI=1S/C22H27ClN4O5/c1-14(2)9-18(22(31)24-20-7-8-26(25-20)11-15(29)13-28)27-12-16(10-21(27)30)32-19-6-4-3-5-17(19)23/h3-8,10,14-15,18,28-29H,9,11-13H2,1-2H3,(H,24,25,31)/t15-,18+/m1/s1
InChI Key HMUMWSORCUWQJO-QAPCUYQASA-N
References
1. Bloomgarden Z. (2019)
Glucokinase and the potential of glucokinase activation in type 2 diabetes.
J Diabetes, 11 (8): 626-627. [PMID:31013387]
2. Grimsby J, Sarabu R, Corbett WL, Haynes NE, Bizzarro FT, Coffey JW, Guertin KR, Hilliard DW, Kester RF, Mahaney PE et al.. (2003)
Allosteric activators of glucokinase: potential role in diabetes therapy.
Science, 301 (5631): 370-3. [PMID:12869762]
3. Sharma P, Singh S, Sharma N, Singla D, Guarve K, Grewal AS. (2022)
Targeting human Glucokinase for the treatment of type 2 diabetes: an overview of allosteric Glucokinase activators.
J Diabetes Metab Disord, 21 (1): 1129-1137. [PMID:35673438]
4. Toulis KA, Nirantharakumar K, Pourzitaki C, Barnett AH, Tahrani AA. (2020)
Glucokinase Activators for Type 2 Diabetes: Challenges and Future Developments.
Drugs, 80 (5): 467-475. [PMID:32162273]
5. Wang P, Liu H, Chen L, Duan Y, Chen Q, Xi S. (2017)
Effects of a Novel Glucokinase Activator, HMS5552, on Glucose Metabolism in a Rat Model of Type 2 Diabetes Mellitus.
J Diabetes Res, 2017: 5812607. [PMID:28191470]
6. Yang W, Zhu D, Gan S, Dong X, Su J, Li W, Jiang H, Zhao W, Yao M, Song W et al.. (2022)
Dorzagliatin add-on therapy to metformin in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled phase 3 trial.
Nat Med, 28 (5): 974-981. [PMID:35551292]
7. Zhu XX, Zhu DL, Li XY, Li YL, Jin XW, Hu TX, Zhao Y, Li YG, Zhao GY, Ren S et al.. (2018)
Dorzagliatin (HMS5552), a novel dual-acting glucokinase activator, improves glycaemic control and pancreatic β-cell function in patients with type 2 diabetes: A 28-day treatment study using biomarker-guided patient selection.
Diabetes Obes Metab, 20 (9): 2113-2120. [PMID:29707866]