Synonyms: HMS-5552 | HMS5552 | RO-5305552 | RO5305552 | Sinogliatin
dorzagliatin is an approved drug (China (2022))
Compound class:
Synthetic organic
Comment: Dorzagliatin (HMS5552) is an allosteric glucokinase (GCK) activator [3,5], that targets both pancreatic and hepatic GCK, and is a 'full' activator that increases GCK's maximum velocity (Vmax) [7]. GCK activators are being developed as novel drugs for the treatment of type 2 diabetes mellitus (T2DM) [1-2,4].
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