Synonyms: D-5261
Compound class:
Synthetic organic
Comment: D5261 is an allosteric inhibitor of neurotrophic receptor tyrosine kinase 1 (NTRK1; also known as tropomyosin receptor kinase A/TrkA; which is a therapeutic target for the treatment of chronis pain) [1].
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
|
References |
1. Guo J, Xiang S, Wang J, Zhou Y, Wang Z, Zhang Z, Ding K, Lu X. (2022)
Discovery of novel TrkA allosteric inhibitors: Structure-based virtual screening, biological evaluation and preliminary SAR studies. Eur J Med Chem, 228: 114022. [PMID:34871843] |