Synonyms: Deltyba® | OPC-67683
delamanid is an approved drug (EMA (2014))
Compound class:
Synthetic organic
Comment: Delamanid is a nitro-dihydro-imidazooxazole derivative with potent antibacterial activity against mycobacteria [1-2]. This drug is used in the treatment of multidrug-resistant tuberculosis (MDR-TB).
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References |
1. Matsumoto M, Hashizume H, Tomishige T, Kawasaki M, Tsubouchi H, Sasaki H, Shimokawa Y, Komatsu M. (2006)
OPC-67683, a nitro-dihydro-imidazooxazole derivative with promising action against tuberculosis in vitro and in mice. PLoS Med, 3 (11): e466. [PMID:17132069] |
2. Sasaki H, Haraguchi Y, Itotani M, Kuroda H, Hashizume H, Tomishige T, Kawasaki M, Matsumoto M, Komatsu M, Tsubouchi H. (2006)
Synthesis and antituberculosis activity of a novel series of optically active 6-nitro-2,3-dihydroimidazo[2,1-b]oxazoles. J Med Chem, 49 (26): 7854-60. [PMID:17181168] |