Synonyms: MK-191 | Pondocillin®
Compound class:
Synthetic organic
Comment: Pivampicillin is a pivaloyloxymethyl ester and prodrug of the β-lactam antibacterial compound ampicillin [1]. It has improved oral bioavailability compared to ampicillin and is rapidly hydrolysed to the active form following absorption from the gastrointestinal tract [3].
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References |
1. Daehne W, Frederiksen E, Gundersen E, Lund F, Morch P, Petersen HJ, Roholt K, Tybring L, Godtfredsen WO. (1970)
Acyloxymethyl esters of ampicillin. J Med Chem, 13 (4): 607-12. [PMID:5452419] |
2. Holme E, Greter J, Jacobson CE, Lindstedt S, Nordin I, Kristiansson B, Jodal U. (1989)
Carnitine deficiency induced by pivampicillin and pivmecillinam therapy. Lancet, 2 (8661): 469-73. [PMID:2570185] |
3. Roholt K, Nielsen B, Kristensen E. (1974)
Clinical pharmacology of pivampicillin. Antimicrob Agents Chemother, 6 (5): 563-71. [PMID:15825306] |