Synonyms: WX-081
Compound class:
Synthetic organic
Comment: Sudapyridine (WX-081) is the lead from a novel diarylpyridine series with antimycobacterial activity and an analogue of bedaquiline [1,3]. Sudapyridine has advanced to clinical evaluation for the treatment of tuberculosis.
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References |
1. Huang Z, Luo W, Xu D, Guo F, Yang M, Zhu Y, Shen L, Chen S, Tang D, Li L et al.. (2022)
Discovery and preclinical profile of sudapyridine (WX-081), a novel anti-tuberculosis agent. Bioorg Med Chem Lett, 71: 128824. [PMID:35636648] |
2. Xiao H, Yu X, Shang Y, Ren R, Xue Y, Dong L, Zhao L, Jiang G, Huang H. (2023)
In vitro and Intracellular Antibacterial Activity of Sudapyridine (WX-081) Against Tuberculosis. Infect Drug Resist, 16: 217-224. [PMID:36647451] |
3. Yao R, Wang B, Fu L, Li L, You K, Li YG, Lu Y. (2022)
Sudapyridine (WX-081), a Novel Compound against Mycobacterium tuberculosis. Microbiol Spectr, 10 (1): e0247721. [PMID:35170994] |