Compound class:
Natural product
Comment: Withaferin A was the first withanolide class phytochemical to be isolated (from Withania somnifera, a.k.a. winter cherry or ashwagandha) [3]. More than 300 withanolides have subsequently been isolated from other plant species, and many pharmacological actions have been associated with them.
![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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References |
1. Chakraborty S, Mallick D, Goswami M, Guengerich FP, Chakrabarty A, Chowdhury G. (2022)
The Natural Products Withaferin A and Withanone from the Medicinal Herb Withania somnifera Are Covalent Inhibitors of the SARS-CoV-2 Main Protease. J Nat Prod, 85 (10): 2340-2350. [PMID:36098617] |
2. Freitas Misakyan MF, Wijeratne EMK, Issa ME, Xu YM, Monteillier A, Gunatilaka AAL, Cuendet M. (2021)
Structure-Activity Relationships of Withanolides as Antiproliferative Agents for Multiple Myeloma: Comparison of Activity in 2D Models and a 3D Coculture Model. J Nat Prod, 84 (8): 2321-2335. [PMID:34445874] |
3. Glotter E. (1991)
Withanolides and related ergostane-type steroids. Nat Prod Rep, 8 (4): 415-40. [PMID:1787922] |
4. Perestelo NR, Llanos GG, Reyes CP, Amesty A, Sooda K, Afshinjavid S, Jiménez IA, Javid F, Bazzocchi IL. (2019)
Expanding the Chemical Space of Withaferin A by Incorporating Silicon To Improve Its Clinical Potential on Human Ovarian Carcinoma Cells. J Med Chem, 62 (9): 4571-4585. [PMID:31008605] |