Synonyms: Bis-(3'-5')-cyclic dimeric guanosine monophosphate | c-di-GMP | cGpGp | dyclic diguanylate monophosphate
Compound class:
Synthetic organic
Comment: Cyclic di-GMP is a dinucleotide of bacterial origin that acts as a signalling molecule in prokaryotes. In mammals it acts as a STING (stimulator of IFN genes) agonist that promotes the type I interferon inflammatory response [1-2].
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References |
1. Burdette DL, Monroe KM, Sotelo-Troha K, Iwig JS, Eckert B, Hyodo M, Hayakawa Y, Vance RE. (2011)
STING is a direct innate immune sensor of cyclic di-GMP. Nature, 478 (7370): 515-8. [PMID:21947006] |
2. Shu C, Yi G, Watts T, Kao CC, Li P. (2012)
Structure of STING bound to cyclic di-GMP reveals the mechanism of cyclic dinucleotide recognition by the immune system. Nat Struct Mol Biol, 19 (7): 722-4. [PMID:22728658] |