orexin-A   

GtoPdb Ligand ID: 1697

Synonyms: hypocretin-1
Species: Human, Mouse, Rat
References
1. Ammoun S, Holmqvist T, Shariatmadari R, Oonk HB, Detheux M, Parmentier M, Akerman KE, Kukkonen JP. (2003)
Distinct recognition of OX1 and OX2 receptors by orexin peptides.
J. Pharmacol. Exp. Ther., 305 (2): 507-14. [PMID:12606634]
2. Darker JG, Porter RA, Eggleston DS, Smart D, Brough SJ, Sabido-David C, Jerman JC. (2001)
Structure-activity analysis of truncated orexin-A analogues at the orexin-1 receptor.
Bioorg. Med. Chem. Lett., 11 (5): 737-40. [PMID:11266181]
3. Hoang QV, Bajic D, Yanagisawa M, Nakajima S, Nakajima Y. (2003)
Effects of orexin (hypocretin) on GIRK channels.
J. Neurophysiol., 90 (2): 693-702. [PMID:12702704]
4. Holmqvist T, Akerman KE, Kukkonen JP. (2001)
High specificity of human orexin receptors for orexins over neuropeptide Y and other neuropeptides.
Neurosci. Lett., 305 (3): 177-80. [PMID:11403934]
5. Holmqvist T, Akerman KE, Kukkonen JP. (2002)
Orexin signaling in recombinant neuron-like cells.
FEBS Lett., 526 (1-3): 11-4. [PMID:12208495]
6. Johansson L, Ekholm ME, Kukkonen JP. (2007)
Regulation of OX1 orexin/hypocretin receptor-coupling to phospholipase C by Ca2+ influx.
Br. J. Pharmacol., 150 (1): 97-104. [PMID:17115071]
7. Johansson L, Ekholm ME, Kukkonen JP. (2008)
Multiple phospholipase activation by OX(1) orexin/hypocretin receptors.
Cell. Mol. Life Sci., 65 (12): 1948-56. [PMID:18488139]
8. Jones DN, Gartlon J, Parker F, Taylor SG, Routledge C, Hemmati P, Munton RP, Ashmeade TE, Hatcher JP, Johns A et al.. (2001)
Effects of centrally administered orexin-B and orexin-A: a role for orexin-1 receptors in orexin-B-induced hyperactivity.
Psychopharmacology (Berl.), 153 (2): 210-8. [PMID:11205421]
9. Jäntti M, Putula J, Somerharju P, Frohman M, Kukkonen J. (2012)
OX(1) orexin/hypocretin receptor activation of phospholipase D.
Br. J. Pharmacol., 165 (4b): 1109-23. [PMID:21718304]
10. Kukkonen JP. (2016)
G-protein-dependency of orexin/hypocretin receptor signalling in recombinant Chinese hamster ovary cells.
Biochem. Biophys. Res. Commun., 476 (4): 379-85. [PMID:27237973]
11. Kukkonen JP. (2016)
OX2 orexin/hypocretin receptor signal transduction in recombinant Chinese hamster ovary cells.
Cell. Signal., 28 (2): 51-60. [PMID:26582739]
12. Langmead CJ, Jerman JC, Brough SJ, Scott C, Porter RA, Herdon HJ. (2004)
Characterisation of the binding of [3H]-SB-674042, a novel nonpeptide antagonist, to the human orexin-1 receptor.
Br. J. Pharmacol., 141 (2): 340-6. [PMID:14691055]
13. Okumura T, Takeuchi S, Motomura W, Yamada H, Egashira Si S, Asahi S, Kanatani A, Ihara M, Kohgo Y. (2001)
Requirement of intact disulfide bonds in orexin-A-induced stimulation of gastric acid secretion that is mediated by OX1 receptor activation.
Biochem. Biophys. Res. Commun., 280 (4): 976-81. [PMID:11162621]
14. Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, Tanaka H, Williams SC, Richardson JA, Kozlowski GP, Wilson S et al.. (1998)
Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior.
Cell, 92 (4): 573-85. [PMID:9491897]
15. Smart D, Jerman JC, Brough SJ, Rushton SL, Murdock PR, Jewitt F, Elshourbagy NA, Ellis CE, Middlemiss DN, Brown F. (1999)
Characterization of recombinant human orexin receptor pharmacology in a Chinese hamster ovary cell-line using FLIPR.
Br. J. Pharmacol., 128 (1): 1-3. [PMID:10498827]
16. Takano S, Kanai S, Hosoya H, Ohta M, Uematsu H, Miyasaka K. (2004)
Orexin-A does not stimulate food intake in old rats.
Am. J. Physiol. Gastrointest. Liver Physiol., 287 (6): G1182-7. [PMID:15271651]
17. Tang J, Chen J, Ramanjaneya M, Punn A, Conner AC, Randeva HS. (2008)
The signalling profile of recombinant human orexin-2 receptor.
Cell. Signal., 20 (9): 1651-61. [PMID:18599270]
18. Turunen PM, Ekholm ME, Somerharju P, Kukkonen JP. (2010)
Arachidonic acid release mediated by OX1 orexin receptors.
Br. J. Pharmacol., 159 (1): 212-21. [PMID:20002100]
19. Turunen PM, Jäntti MH, Kukkonen JP. (2012)
OX1 orexin/hypocretin receptor signaling through arachidonic acid and endocannabinoid release.
Mol. Pharmacol., 82 (2): 156-67. [PMID:22550093]
20. Zhu Y, Miwa Y, Yamanaka A, Yada T, Shibahara M, Abe Y, Sakurai T, Goto K. (2003)
Orexin receptor type-1 couples exclusively to pertussis toxin-insensitive G-proteins, while orexin receptor type-2 couples to both pertussis toxin-sensitive and -insensitive G-proteins.
J Pharmacol Sci, 92: 259-266. [PMID:12890892]