INSL5   Click here for help

GtoPdb Ligand ID: 2000

Synonyms: insulin-like peptide 5
Species: Human
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References
1. Ang SY, Hutchinson DS, Patil N, Evans BA, Bathgate RAD, Halls ML, Hossain MA, Summers RJ, Kocan M. (2017)
Signal transduction pathways activated by insulin-like peptide 5 at the relaxin family peptide RXFP4 receptor.
Br J Pharmacol, 174 (10): 1077-1089. [PMID:27243554]
2. Belgi A, Bathgate RA, Kocan M, Patil N, Zhang S, Tregear GW, Wade JD, Hossain MA. (2013)
Minimum active structure of insulin-like peptide 5.
J Med Chem, 56 (23): 9509-16. [PMID:24188028]
3. Khalaf MS, Coles MP, Hitchcock PB. (2008)
A structural, theoretical and coordinative evaluation of the bicyclic guanidinate derived from 1,4,6-triazabicyclo[3.3.0]oct-4-ene.
Dalton Trans, (32): 4288-95. [PMID:18682868]
4. Liu C, Chen J, Kuei C, Sutton S, Nepomuceno D, Bonaventure P, Lovenberg TW. (2005)
Relaxin-3/insulin-like peptide 5 chimeric peptide, a selective ligand for G protein-coupled receptor (GPCR)135 and GPCR142 over leucine-rich repeat-containing G protein-coupled receptor 7.
Mol Pharmacol, 67 (1): 231-40. [PMID:15465925]
5. Liu C, Chen J, Sutton S, Roland B, Kuei C, Farmer N, Sillard R, Lovenberg TW. (2003)
Identification of relaxin-3/INSL7 as a ligand for GPCR142.
J Biol Chem, 278 (50): 50765-70. [PMID:14522967]
6. Liu C, Kuei C, Sutton S, Chen J, Bonaventure P, Wu J, Nepomuceno D, Kamme F, Tran DT, Zhu J et al.. (2005)
INSL5 is a high affinity specific agonist for GPCR142 (GPR100).
J Biol Chem, 280 (1): 292-300. [PMID:15525639]
7. Patil NA, Hughes RA, Rosengren KJ, Kocan M, Ang SY, Tailhades J, Separovic F, Summers RJ, Grosse J, Wade JD et al.. (2016)
Engineering of a Novel Simplified Human Insulin-Like Peptide 5 Agonist.
J Med Chem, 59 (5): 2118-25. [PMID:26824523]
8. Shabanpoor F, Akhter Hossain M, Ryan PJ, Belgi A, Layfield S, Kocan M, Zhang S, Samuel CS, Gundlach AL, Bathgate RA et al.. (2012)
Minimization of human relaxin-3 leading to high-affinity analogues with increased selectivity for relaxin-family peptide 3 receptor (RXFP3) over RXFP1.
J Med Chem, 55 (4): 1671-81. [PMID:22257012]
9. Zhu J, Kuei C, Sutton S, Kamme F, Yu J, Bonaventure P, Atack J, Lovenberg TW, Liu C. (2008)
Identification of the domains in RXFP4 (GPCR142) responsible for the high affinity binding and agonistic activity of INSL5 at RXFP4 compared to RXFP3 (GPCR135).
Eur J Pharmacol, 590 (1-3): 43-52. [PMID:18582868]