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Synonyms: pasireotide diaspartate | Signifor® | SOM 230 | SOM 320 | SOM-230
pasireotide is an approved drug (FDA and EMA (2012))
Compound class: Peptide or derivative
Comment: Cyclic peptide analog of somatostatin. This compound is represented on ChEMBL with slightly different stereochemistry by CHEMBL3039583.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Cescato R, Loesch KA, Waser B, Mäcke HR, Rivier JE, Reubi JC, Schonbrunn A. (2010)
Agonist-biased signaling at the sst2A receptor: the multi-somatostatin analogs KE108 and SOM230 activate and antagonize distinct signaling pathways.
Mol Endocrinol, 24 (1): 240-9. [PMID:19910453]
2. Kao YJ, Ghosh M, Schonbrunn A. (2011)
Ligand-dependent mechanisms of sst2A receptor trafficking: role of site-specific phosphorylation and receptor activation in the actions of biased somatostatin agonists.
Mol Endocrinol, 25 (6): 1040-54. [PMID:21493671]
3. Schmid HA, Schoeffter P. (2004)
Functional activity of the multiligand analog SOM230 at human recombinant somatostatin receptor subtypes supports its usefulness in neuroendocrine tumors.
Neuroendocrinology, 80 Suppl 1: 47-50. [PMID:15477717]