pasireotide

Ligand id: 2018

Name: pasireotide

Structure and Physico-chemical Properties

2D Structure
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View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at GPCRs
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
SST2 receptor Rn Agonist Agonist 7.8 – 9.1 pEC50 - 1-2
pEC50 7.8 – 9.1 (EC50 1.75x10-8 – 8.6x10-10 M) [1-2]
SST2 receptor Rn Agonist Partial agonist 7.6 pEC50 - 2
pEC50 7.6 (EC50 2.33x10-8 M) [2]
SST2 receptor Rn Antagonist Antagonist <5.0 pEC50 - 1
pEC50 <5.0 (EC50 >1x10-5 M) [1]
SST5 receptor Hs Agonist Full agonist 9.8 pIC50 - 3
pIC50 9.8 [3]
SST2 receptor Hs Agonist Full agonist 9.0 pIC50 - 3
pIC50 9.0 [3]
SST3 receptor Hs Agonist Full agonist 8.8 pIC50 - 3
pIC50 8.8 [3]
SST1 receptor Hs Agonist Full agonist 8.0 pIC50 - 3
pIC50 8.0 [3]