tetraethylammonium   Click here for help

GtoPdb Ligand ID: 2343

Abbreviated name: TEA
PDB Ligand
Compound class: Synthetic organic
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 0
Hydrogen bond donors 0
Rotatable bonds 4
Topological polar surface area 0
Molecular weight 130.16
XLogP 1.56
No. Lipinski's rules broken 0
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Canonical SMILES CC[N+](CC)(CC)CC
Isomeric SMILES CC[N+](CC)(CC)CC
InChI InChI=1S/C8H20N/c1-5-9(6-2,7-3)8-4/h5-8H2,1-4H3/q+1
1. Bal M, Zhang J, Zaika O, Hernandez CC, Shapiro MS. (2008)
Homomeric and heteromeric assembly of KCNQ (Kv7) K+ channels assayed by total internal reflection fluorescence/fluorescence resonance energy transfer and patch clamp analysis.
J Biol Chem, 283 (45): 30668-76. [PMID:18786918]
2. Bardien-Kruger S, Wulff H, Arieff Z, Brink P, Chandy KG, Corfield V. (2002)
Characterisation of the human voltage-gated potassium channel gene, KCNA7, a candidate gene for inherited cardiac disorders, and its exclusion as cause of progressive familial heart block I (PFHBI).
Eur J Hum Genet, 10 (1): 36-43. [PMID:11896454]
3. Bhattacharjee A, Kaczmarek LK. (2005)
For K+ channels, Na+ is the new Ca2+.
Trends Neurosci, 28 (8): 422-8. [PMID:15979166]
4. Engel K, Wang J. (2005)
Interaction of organic cations with a newly identified plasma membrane monoamine transporter.
Mol Pharmacol, 68 (5): 1397-407. [PMID:16099839]
5. Gorboulev V, Ulzheimer JC, Akhoundova A, Ulzheimer-Teuber I, Karbach U, Quester S, Baumann C, Lang F, Busch AE, Koepsell H. (1997)
Cloning and characterization of two human polyspecific organic cation transporters.
DNA Cell Biol, 16 (7): 871-81. [PMID:9260930]
6. Grissmer S, Nguyen AN, Aiyar J, Hanson DC, Mather RJ, Gutman GA, Karmilowicz MJ, Auperin DD, Chandy KG. (1994)
Pharmacological characterization of five cloned voltage-gated K+ channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines.
Mol Pharmacol, 45 (6): 1227-34. [PMID:7517498]
7. Grupe A, Schröter KH, Ruppersberg JP, Stocker M, Drewes T, Beckh S, Pongs O. (1990)
Cloning and expression of a human voltage-gated potassium channel. A novel member of the RCK potassium channel family.
EMBO J, 9 (6): 1749-56. [PMID:2347305]
8. Hadley JK, Noda M, Selyanko AA, Wood IC, Abogadie FC, Brown DA. (2000)
Differential tetraethylammonium sensitivity of KCNQ1-4 potassium channels.
Br J Pharmacol, 129 (3): 413-5. [PMID:10711337]
9. He Y, Kang Y, Leung YM, Xia F, Gao X, Xie H, Gaisano HY, Tsushima RG. (2006)
Modulation of Kv2.1 channel gating and TEA sensitivity by distinct domains of SNAP-25.
Biochem J, 396 (2): 363-9. [PMID:16478442]
10. Jiang B, Sun X, Cao K, Wang R. (2002)
Endogenous Kv channels in human embryonic kidney (HEK-293) cells.
Mol Cell Biochem, 238 (1-2): 69-79. [PMID:12349911]
11. Juvin V, Penna A, Chemin J, Lin YL, Rassendren FA. (2007)
Pharmacological characterization and molecular determinants of the activation of transient receptor potential V2 channel orthologs by 2-aminoethoxydiphenyl borate.
Mol Pharmacol, 72 (5): 1258-68. [PMID:17673572]
12. Kalman K, Nguyen A, Tseng-Crank J, Dukes ID, Chandy G, Hustad CM, Copeland NG, Jenkins NA, Mohrenweiser H, Brandriff B et al.. (1998)
Genomic organization, chromosomal localization, tissue distribution, and biophysical characterization of a novel mammalian Shaker-related voltage-gated potassium channel, Kv1.7.
J Biol Chem, 273 (10): 5851-7. [PMID:9488722]
13. Lang R, Lee G, Liu W, Tian S, Rafi H, Orias M, Segal AS, Desir GV. (2000)
KCNA10: a novel ion channel functionally related to both voltage-gated potassium and CNG cation channels.
Am J Physiol Renal Physiol, 278 (6): F1013-21. [PMID:10836990]
14. Lerche C, Scherer CR, Seebohm G, Derst C, Wei AD, Busch AE, Steinmeyer K. (2000)
Molecular cloning and functional expression of KCNQ5, a potassium channel subunit that may contribute to neuronal M-current diversity.
J Biol Chem, 275 (29): 22395-400. [PMID:10787416]
15. Lien CC, Martina M, Schultz JH, Ehmke H, Jonas P. (2002)
Gating, modulation and subunit composition of voltage-gated K(+) channels in dendritic inhibitory interneurones of rat hippocampus.
J Physiol (Lond.), 538 (Pt 2): 405-19. [PMID:11790809]
16. Makhina EN, Kelly AJ, Lopatin AN, Mercer RW, Nichols CG. (1994)
Cloning and expression of a novel human brain inward rectifier potassium channel.
J Biol Chem, 269 (32): 20468-74. [PMID:8051145]
17. Rettig J, Wunder F, Stocker M, Lichtinghagen R, Mastiaux F, Beckh S, Kues W, Pedarzani P, Schröter KH, Ruppersberg JP. (1992)
Characterization of a Shaw-related potassium channel family in rat brain.
EMBO J, 11 (7): 2473-86. [PMID:1378392]
18. Santi CM, Ferreira G, Yang B, Gazula VR, Butler A, Wei A, Kaczmarek LK, Salkoff L. (2006)
Opposite regulation of Slick and Slack K+ channels by neuromodulators.
J Neurosci, 26 (19): 5059-68. [PMID:16687497]
19. Schmalz F, Kinsella J, Koh SD, Vogalis F, Schneider A, Flynn ER, Kenyon JL, Horowitz B. (1998)
Molecular identification of a component of delayed rectifier current in gastrointestinal smooth muscles.
Am J Physiol, 274 (5 Pt 1): G901-11. [PMID:9612272]
20. Schroeder BC, Hechenberger M, Weinreich F, Kubisch C, Jentsch TJ. (2000)
KCNQ5, a novel potassium channel broadly expressed in brain, mediates M-type currents.
J Biol Chem, 275 (31): 24089-95. [PMID:10816588]
21. Schröter KH, Ruppersberg JP, Wunder F, Rettig J, Stocker M, Pongs O. (1991)
Cloning and functional expression of a TEA-sensitive A-type potassium channel from rat brain.
FEBS Lett, 278 (2): 211-6. [PMID:1840526]
22. Vega-Saenz de Miera E, Moreno H, Fruhling D, Kentros C, Rudy B. (1992)
Cloning of ShIII (Shaw-like) cDNAs encoding a novel high-voltage-activating, TEA-sensitive, type-A K+ channel.
Proc Biol Sci, 248 (1321): 9-18. [PMID:1381835]
23. Wang J. (2016)
The plasma membrane monoamine transporter (PMAT): Structure, function, and role in organic cation disposition.
Clin Pharmacol Ther, 100 (5): 489-499. [PMID:27506881]
24. Weatherall KL, Goodchild SJ, Jane DE, Marrion NV. (2010)
Small conductance calcium-activated potassium channels: from structure to function.
Prog Neurobiol, 91 (3): 242-55. [PMID:20359520]
25. Wickenden AD, Yu W, Zou A, Jegla T, Wagoner PK. (2000)
Retigabine, a novel anti-convulsant, enhances activation of KCNQ2/Q3 potassium channels.
Mol Pharmacol, 58 (3): 591-600. [PMID:10953053]