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Synonyms: Corlanor® | Corlentor® | Procoralan® | S-16257
ivabradine is an approved drug (EMA (2005), FDA (2015))
Compound class: Synthetic organic
Comment: Marketed drugs contain ivabradine hydrochloride (PubChem CID 3045381).
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
View more information in the IUPHAR Pharmacology Education Project: ivabradine
1. Bucchi A, Tognati A, Milanesi R, Baruscotti M, DiFrancesco D. (2006)
Properties of ivabradine-induced block of HCN1 and HCN4 pacemaker channels.
J Physiol (Lond.), 572 (Pt 2): 335-46. [PMID:16484306]
2. DiFrancesco D, Camm JA. (2004)
Heart rate lowering by specific and selective I(f) current inhibition with ivabradine: a new therapeutic perspective in cardiovascular disease.
Drugs, 64 (16): 1757-65. [PMID:15301560]
3. Mar PL, Raj SR. (2020)
Postural Orthostatic Tachycardia Syndrome: Mechanisms and New Therapies.
Annu Rev Med, 71: 235-248. [PMID:31412221]
4. Stieber J, Wieland K, Stöckl G, Ludwig A, Hofmann F. (2006)
Bradycardic and proarrhythmic properties of sinus node inhibitors.
Mol Pharmacol, 69 (4): 1328-37. [PMID:16387796]