La3+   Click here for help

GtoPdb Ligand ID: 2434

Synonyms: lanthanum ion
Compound class: Inorganic
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
References
1. Chen XZ, Vassilev PM, Basora N, Peng JB, Nomura H, Segal Y, Brown EM, Reeders ST, Hediger MA, Zhou J. (1999)
Polycystin-L is a calcium-regulated cation channel permeable to calcium ions.
Nature, 401 (6751): 383-6. [PMID:10517637]
2. Grimm C, Kraft R, Sauerbruch S, Schultz G, Harteneck C. (2003)
Molecular and functional characterization of the melastatin-related cation channel TRPM3.
J Biol Chem, 278 (24): 21493-501. [PMID:12672799]
3. Halaszovich CR, Zitt C, Jungling E, Luckhoff A. (2000)
Inhibition of TRP3 channels by lanthanides. Block from the cytosolic side of the plasma membrane.
J Biol Chem, 275 (48): 37423-8. [PMID:10970899]
4. Inoue R, Okada T, Onoue H, Hara Y, Shimizu S, Naitoh S, Ito Y, Mori Y. (2001)
The transient receptor potential protein homologue TRP6 is the essential component of vascular alpha(1)-adrenoceptor-activated Ca(2+)-permeable cation channel.
Circ Res, 88 (3): 325-32. [PMID:11179201]
5. Jung S, Mühle A, Schaefer M, Strotmann R, Schultz G, Plant TD. (2003)
Lanthanides potentiate TRPC5 currents by an action at extracellular sites close to the pore mouth.
J Biol Chem, 278 (6): 3562-71. [PMID:12456670]
6. Lee N, Chen J, Sun L, Wu S, Gray KR, Rich A, Huang M, Lin JH, Feder JN, Janovitz EB et al.. (2003)
Expression and characterization of human transient receptor potential melastatin 3 (hTRPM3).
J Biol Chem, 278 (23): 20890-7. [PMID:12672827]
7. Okada T, Inoue R, Yamazaki K, Maeda A, Kurosaki T, Yamakuni T, Tanaka I, Shimizu S, Ikenaka K, Imoto K et al.. (1999)
Molecular and functional characterization of a novel mouse transient receptor potential protein homologue TRP7. Ca(2+)-permeable cation channel that is constitutively activated and enhanced by stimulation of G protein-coupled receptor.
J Biol Chem, 274 (39): 27359-70. [PMID:10488066]
8. Runnels LW, Yue L, Clapham DE. (2001)
TRP-PLIK, a bifunctional protein with kinase and ion channel activities.
Science, 291 (5506): 1043-7. [PMID:11161216]
9. Strübing C, Krapivinsky G, Krapivinsky L, Clapham DE. (2001)
TRPC1 and TRPC5 form a novel cation channel in mammalian brain.
Neuron, 29 (3): 645-55. [PMID:11301024]