clofilium   Click here for help

GtoPdb Ligand ID: 2507

Compound class: Synthetic organic
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 0
Hydrogen bond donors 0
Rotatable bonds 13
Topological polar surface area 0
Molecular weight 338.26
XLogP 7.19
No. Lipinski's rules broken 2
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Canonical SMILES CCCCCCC[N+](CCCCc1ccc(cc1)Cl)(CC)CC
Isomeric SMILES CCCCCCC[N+](CCCCc1ccc(cc1)Cl)(CC)CC
InChI InChI=1S/C21H37ClN/c1-4-7-8-9-11-18-23(5-2,6-3)19-12-10-13-20-14-16-21(22)17-15-20/h14-17H,4-13,18-19H2,1-3H3/q+1
1. de Los Angeles Tejada M, Stolpe K, Meinild AK, Klaerke DA. (2012)
Clofilium inhibits Slick and Slack potassium channels.
Biologics, 6: 465-70. [PMID:23271893]
2. Gessner G, Heinemann SH. (2003)
Inhibition of hEAG1 and hERG1 potassium channels by clofilium and its tertiary analogue LY97241.
Br J Pharmacol, 138 (1): 161-71. [PMID:12522086]
3. Malayev AA, Nelson DJ, Philipson LH. (1995)
Mechanism of clofilium block of the human Kv1.5 delayed rectifier potassium channel.
Mol Pharmacol, 47 (1): 198-205. [PMID:7838129]
4. Niemeyer MI, Cid LP, Barros LF, Sepúlveda FV. (2001)
Modulation of the two-pore domain acid-sensitive K+ channel TASK-2 (KCNK5) by changes in cell volume.
J Biol Chem, 276 (46): 43166-74. [PMID:11560934]