margatoxin   Click here for help

GtoPdb Ligand ID: 2547

Synonyms: MgTx | potassium channel toxin α-KTx 2.2
Comment: From Centruroides margaritatus (Scorpion)
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1. Bartok A, Toth A, Somodi S, Szanto TG, Hajdu P, Panyi G, Varga Z. (2014)
Margatoxin is a non-selective inhibitor of human Kv1.3 K+ channels.
Toxicon, 87: 6-16. [PMID:24878374]
2. Garcia-Calvo M, Leonard RJ, Novick J, Stevens SP, Schmalhofer W, Kaczorowski GJ, Garcia ML. (1993)
Purification, characterization, and biosynthesis of margatoxin, a component of Centruroides margaritatus venom that selectively inhibits voltage-dependent potassium channels.
J Biol Chem, 268 (25): 18866-74. [PMID:8360176]
3. Ghanshani S, Wulff H, Miller MJ, Rohm H, Neben A, Gutman GA, Cahalan MD, Chandy KG. (2000)
Up-regulation of the IKCa1 potassium channel during T-cell activation. Molecular mechanism and functional consequences.
J Biol Chem, 275 (47): 37137-49. [PMID:10961988]
4. Kalman K, Nguyen A, Tseng-Crank J, Dukes ID, Chandy G, Hustad CM, Copeland NG, Jenkins NA, Mohrenweiser H, Brandriff B et al.. (1998)
Genomic organization, chromosomal localization, tissue distribution, and biophysical characterization of a novel mammalian Shaker-related voltage-gated potassium channel, Kv1.7.
J Biol Chem, 273 (10): 5851-7. [PMID:9488722]
5. Koch RO, Wanner SG, Koschak A, Hanner M, Schwarzer C, Kaczorowski GJ, Slaughter RS, Garcia ML, Knaus HG. (1997)
Complex subunit assembly of neuronal voltage-gated K+ channels. Basis for high-affinity toxin interactions and pharmacology.
J Biol Chem, 272 (44): 27577-81. [PMID:9346893]