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Synonyms: AM-80 | AM80 | Amnolake® | retinobenzoic acid
tamibarotene is an approved drug
Compound class: Synthetic organic
Comment: This compound is a retinoic acid receptor α (RARα) agonist .
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Kagechika H, Kawachi E, Hashimoto Y, Himi T, Shudo K. (1988)
Retinobenzoic acids. 1. Structure-activity relationships of aromatic amides with retinoidal activity.
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Activation of retinoid X receptors induces apoptosis in HL-60 cell lines.
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Therapeutic applications for ligands of retinoid receptors.
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Toward the development of innovative bifunctional agents to induce differentiation and to promote apoptosis in leukemia: clinical candidates and perspectives.
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