Synonyms: XCT 790 | XCT-790
Compound class:
Synthetic organic
Comment: XCT790 is a selective estrogen-related receptor α (ERRα) antagonist/inverse agonist [1-2].
![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
|
References |
1. Kong X, Fan H, Liu X, Wang R, Liang J, Gupta N, Chen Y, Fang F, Chang Y. (2009)
Peroxisome proliferator-activated receptor gamma coactivator-1alpha enhances antiproliferative activity of 5'-deoxy-5-fluorouridine in cancer cells through induction of uridine phosphorylase. Mol Pharmacol, 76 (4): 854-60. [PMID:19602572] |
2. Lanvin O, Bianco S, Kersual N, Chalbos D, Vanacker JM. (2007)
Potentiation of ICI182,780 (Fulvestrant)-induced estrogen receptor-alpha degradation by the estrogen receptor-related receptor-alpha inverse agonist XCT790. J Biol Chem, 282 (39): 28328-34. [PMID:17631492] |
3. Suetsugi M, Su L, Karlsberg K, Yuan YC, Chen S. (2003)
Flavone and isoflavone phytoestrogens are agonists of estrogen-related receptors. Mol Cancer Res, 1 (13): 981-91. [PMID:14638870] |
4. Willy PJ, Murray IR, Qian J, Busch BB, Stevens WC, Martin R, Mohan R, Zhou S, Ordentlich P, Wei P, Sapp DW, Horlick RA, Heyman RA, Schulman IG. (2004)
Regulation of PPARgamma coactivator 1alpha (PGC-1alpha) signaling by an estrogen-related receptor alpha (ERRalpha) ligand. Proc Natl Acad Sci USA, 101 (24): 8912-7. [PMID:15184675] |
5. Zuercher WJ, Gaillard S, Orband-Miller LA, Chao EY, Shearer BG, Jones DG, Miller AB, Collins JL, McDonnell DP, Willson TM. (2005)
Identification and structure-activity relationship of phenolic acyl hydrazones as selective agonists for the estrogen-related orphan nuclear receptors ERRbeta and ERRgamma. J Med Chem, 48 (9): 3107-9. [PMID:15857113] |