1-naphthylpiperazine

Ligand id: 3

Name: 1-naphthylpiperazine

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 1
Topological polar surface area 15.27
Molecular weight 212.13
XLogP 3.02
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
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Cloning and characterization of the guinea pig 5-HT1F receptor subtype: a comparison of the pharmacological profile to the human species homolog.
Neuropharmacology, 36 (4-5): 569-76. [PMID:9225282]
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Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase.
Proc. Natl. Acad. Sci. U.S.A., 90 (2): 408-12. [PMID:8380639]
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Molecular cloning and pharmacological characterization of the guinea pig 5-HT1E receptor.
Eur. J. Pharmacol., 484 (2-3): 127-39. [PMID:14744596]
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Cloning of a novel human serotonin receptor (5-HT7) positively linked to adenylate cyclase.
J. Biol. Chem., 268 (31): 23422-6. [PMID:8226867]
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5-HT1B receptor antagonist properties of novel arylpiperazide derivatives of 1-naphthylpiperazine.
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Molecular cloning, functional expression, and mRNA tissue distribution of the human 5-hydroxytryptamine2B receptor.
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Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs.
Mol. Pharmacol., 43 (3): 320-7. [PMID:7680751]
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Two amino acid differences in the sixth transmembrane domain are partially responsible for the pharmacological differences between the 5-HT1D beta and 5-HT1E 5-hydroxytryptamine receptors.
J. Neurochem., 67 (5): 2096-103. [PMID:8863519]
9. Shen Y, Monsma Jr FJ, Metcalf MA, Jose PA, Hamblin MW, Sibley DR. (1993)
Molecular cloning and expression of a 5-hydroxytryptamine7 serotonin receptor subtype.
J. Biol. Chem., 268 (24): 18200-4. [PMID:8394362]
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Pharmacological characteristics of the newly cloned rat 5-hydroxytryptamine2F receptor.
Mol. Pharmacol., 43 (3): 419-26. [PMID:8450835]
11. Wainscott DB, Sasso DA, Kursar JD, Baez M, Lucaites VL, Nelson DL. (1998)
[3H]Rauwolscine: an antagonist radioligand for the cloned human 5-hydroxytryptamine2b (5-HT2B) receptor.
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Human serotonin 1D receptor is encoded by a subfamily of two distinct genes: 5-HT1D alpha and 5-HT1D beta.
Proc. Natl. Acad. Sci. U.S.A., 89 (8): 3630-4. [PMID:1565658]