Ligand id: 3411

Name: [3H]LXA4    

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 4
Rotatable bonds 14
Topological polar surface area 97.99
Molecular weight 354.24
XLogP 3.04
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

1. Chiang N, Takano T, Arita M, Watanabe S, Serhan CN. (2003)
A novel rat lipoxin A4 receptor that is conserved in structure and function.
Br. J. Pharmacol., 139 (1): 89-98. [PMID:12746227]
2. Fiore S, Maddox JF, Perez HD, Serhan CN. (1994)
Identification of a human cDNA encoding a functional high affinity lipoxin A4 receptor.
J. Exp. Med., 180: 253-260. [PMID:8006586]
3. Fiore S, Ryeom SW, Weller PF, Serhan CN. (1992)
Lipoxin recognition sites. Specific binding of labeled lipoxin A4 with human neutrophils.
J. Biol. Chem., 267 (23): 16168-76. [PMID:1322894]
4. Takano T, Fiore S, Maddox JF, Brady HR, Petasis NA, Serhan CN. (1997)
Aspirin-triggered 15-epi-lipoxin A4 (LXA4) and LXA4 stable analogues are potent inhibitors of acute inflammation: evidence for anti-inflammatory receptors.
J. Exp. Med., 185: 1693-1704. [PMID:9151906]