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Synonyms: metanicotine | RJR-2403 | TC 2403 | TC-2403 | TC2403 | trans-metanicotine
Compound class: Synthetic organic
Comment: Rivanicline is an agonist at neural nicotinic acetylcholine receptors, binding primarily to the α4β2 subtype . Potential clinical use of rivanicline is discussed in patent US5616707 .
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Bencherif M, Lovette ME, Fowler KW, Arrington S, Reeves L, Caldwell WS, Lippiello PM. (1996)
RJR-2403: a nicotinic agonist with CNS selectivity I. In vitro characterization.
J. Pharmacol. Exp. Ther., 279 (3): 1413-21. [PMID:8968366]
2. Crooks PA, Caldwell WS, Dull GM, Bhatti BS, Deo NM, Ravard A. (1997)
Compounds which are useful for prevention and treatment of central nervous system disorders.
Patent number: US5616707 A. Assignee: Crooks PA, Caldwell WS, Dull GM, Bhatti BS, Deo NM, Ravard A.. Priority date: 01/12/2015. Publication date: 01/04/1997.
3. Dogruer D, Lee M, Dukat M, Damaj MI, Martin BR, Glennon RA. (2004)
3-(4-Aminobutyn-1-yl)pyridines: binding at alpha 4 beta 2 nicotinic cholinergic receptors.
Bioorg. Med. Chem. Lett., 14 (2): 523-6. [PMID:14698195]