[3H]ZM 241385   Click here for help

GtoPdb Ligand ID: 455

Synonyms: [3H]-ZM241385
 Ligand is labelled  Ligand is radioactive
Compound class: Synthetic organic
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 6
Hydrogen bond donors 3
Rotatable bonds 5
Topological polar surface area 127.39
Molecular weight 337.13
XLogP 1.56
No. Lipinski's rules broken 0
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Canonical SMILES Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1
Isomeric SMILES c1([3H])cc(CCNc2nc(N)n3c(n2)nc(n3)c2ccco2)ccc1O
InChI InChI=1S/C16H15N7O2/c17-14-20-15(18-8-7-10-3-5-11(24)6-4-10)21-16-19-13(22-23(14)16)12-2-1-9-25-12/h1-6,9,24H,7-8H2,(H3,17,18,19,20,21,22)/i5T
1. Alexander SP, Millns PJ. (2001)
[(3)H]ZM241385--an antagonist radioligand for adenosine A(2A) receptors in rat brain.
Eur J Pharmacol, 411 (3): 205-10. [PMID:11164377]
2. Feoktistov I, Garland EM, Goldstein AE, Zeng D, Belardinelli L, Wells JN, Biaggioni I. (2001)
Inhibition of human mast cell activation with the novel selective adenosine A(2B) receptor antagonist 3-isobutyl-8-pyrrolidinoxanthine (IPDX)(2).
Biochem Pharmacol, 62 (9): 1163-73. [PMID:11705449]
3. Gao ZG, Jiang Q, Jacobson KA, Ijzerman AP. (2000)
Site-directed mutagenesis studies of human A(2A) adenosine receptors: involvement of glu(13) and his(278) in ligand binding and sodium modulation.
Biochem Pharmacol, 60 (5): 661-8. [PMID:10927024]
4. Ji XD, Jacobson KA. (1999)
Use of the triazolotriazine [3H]ZM 241385 as a radioligand at recombinant human A2B adenosine receptors.
Drug Des Discov, 16 (3): 217-26. [PMID:10624567]
5. Stewart M, Steinig AG, Ma C, Song JP, McKibben B, Castelhano AL, MacLennan SJ. (2004)
[3H]OSIP339391, a selective, novel, and high affinity antagonist radioligand for adenosine A2B receptors.
Biochem Pharmacol, 68 (2): 305-12. [PMID:15194002]