IL-5   Click here for help

GtoPdb Ligand ID: 4997

Immunopharmacology Ligand
Comment: IL-5 is one of the hematopoietic family cytokines. Unlike other family members IL-3 and GM-CSF, IL-5 is a homodimer, consisting of two identical amino acid chains linked by two disulphide bonds
Species: Human
1. Bodmer MW, Athwal DS, Emtage JS. (1999)
Interleukin-5 specific recombinant antibodies.
Patent number: US5998586. Assignee: Celltech Therapeutics, Limited. Priority date: 17/06/1994. Publication date: 07/12/1999.
2. Hart TK, Cook RM, Zia-Amirhosseini P, Minthorn E, Sellers TS, Maleeff BE, Eustis S, Schwartz LW, Tsui P, Appelbaum ER et al.. (2001)
Preclinical efficacy and safety of mepolizumab (SB-240563), a humanized monoclonal antibody to IL-5, in cynomolgus monkeys.
J Allergy Clin Immunol, 108 (2): 250-7. [PMID:11496242]
3. Takatsu K. (2011)
Interleukin-5 and IL-5 receptor in health and diseases.
Proc Jpn Acad, Ser B, Phys Biol Sci, 87 (8): 463-85. [PMID:21986312]