resiquimod

Ligand id: 5051

Name: resiquimod

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 5
Topological polar surface area 86.19
Molecular weight 314.17
XLogP 1.94
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Hemmi H, Kaisho T, Takeuchi O, Sato S, Sanjo H, Hoshino K, Horiuchi T, Tomizawa H, Takeda K, Akira S. (2002)
Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway.
Nat. Immunol., 3 (2): 196-200. [PMID:11812998]
2. Jurk M, Heil F, Vollmer J, Schetter C, Krieg AM, Wagner H, Lipford G, Bauer S. (2002)
Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848.
Nat. Immunol., 3 (6): 499. [PMID:12032557]
3. Larson P, Kucaba TA, Xiong Z, Olin M, Griffith TS, Ferguson DM. (2017)
Design and Synthesis of N1-Modified Imidazoquinoline Agonists for Selective Activation of Toll-like Receptors 7 and 8.
ACS Med. Chem. Lett., Epub ahead of print.
4. Stockfleth E, Hofbauer GFL, Reinhold U, Popp G, Hengge UR, Szeimies RM, BrĂ¼ning H, Anliker M, Hunger T, Dummer R et al.. (2019)
Topical resiquimod dosing regimens in patients with multiple actinic keratoses: a multicentre, partly placebo-controlled, double-blind clinical trial.
Br. J. Dermatol., 180 (2): 297-305. [PMID:30171698]