BRL 44408   Click here for help

GtoPdb Ligand ID: 525

Synonyms: BRL-44408 | BRL44408
Compound class: Synthetic organic
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 2
Topological polar surface area 27.63
Molecular weight 215.14
XLogP 1.42
No. Lipinski's rules broken 0
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Canonical SMILES CC1N(CC2=NCCN2)Cc2c1cccc2
Isomeric SMILES CC1N(CC2=NCCN2)Cc2c1cccc2
InChI InChI=1S/C13H17N3/c1-10-12-5-3-2-4-11(12)8-16(10)9-13-14-6-7-15-13/h2-5,10H,6-9H2,1H3,(H,14,15)
1. Proudman RGW, Akinaga J, Baker JG. (2022)
The affinity and selectivity of α-adrenoceptor antagonists, antidepressants and antipsychotics for the human α2A, α2B, and α2C-adrenoceptors and comparison with human α1 and β-adrenoceptors.
Pharmacol Res Perspect, 10 (2): e00936. [PMID:35224877]
2. Uhlén S, Porter AC, Neubig RR. (1994)
The novel alpha-2 adrenergic radioligand [3H]-MK912 is alpha-2C selective among human alpha-2A, alpha-2B and alpha-2C adrenoceptors.
J Pharmacol Exp Ther, 271 (3): 1558-65. [PMID:7996470]
3. Young P, Berge J, Chapman H, Cawthorne MA. (1989)
Novel alpha 2-adrenoceptor antagonists show selectivity for alpha 2A- and alpha 2B-adrenoceptor subtypes.
Eur J Pharmacol, 168 (3): 381-6. [PMID:2573535]