Ligand id: 569

Name: carazolol

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 3
Rotatable bonds 6
Topological polar surface area 57.28
Molecular weight 298.17
XLogP 3.27
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

1. Innis RB, Corrēa FM, Synder SH. (1979)
Carazolol, an extremely potent beta-adrenergic blocker: binding to beta-receptors in brain membranes.
Life Sci., 24 (24): 2255-64. [PMID:41147]
2. Méjean A, Guillaume JL, Strosberg AD. (1995)
Carazolol: a potent, selective beta 3-adrenoceptor agonist.
Eur. J. Pharmacol., 291 (3): 359-66. [PMID:8719421]
3. Sabio M, Jones K, Topiol S. (2008)
Use of the X-ray structure of the beta2-adrenergic receptor for drug discovery. Part 2: Identification of active compounds.
Bioorg. Med. Chem. Lett., 18 (20): 5391-5. [PMID:18829308]