carazolol

Ligand id: 569

Name: carazolol

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 3
Rotatable bonds 6
Topological polar surface area 57.28
Molecular weight 298.17
XLogP 3.27
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Selectivity at GPCRs
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
β2-adrenoceptor Hs Antagonist Antagonist 9.9 pKi - 3
pKi 9.9 (Ki 1.14x10-10 M) [3]
β3-adrenoceptor Hs Agonist Full agonist 8.7 pKi - 2
pKi 8.7 (Ki 1.99x10-9 M) [2]
β3-adrenoceptor Mm Agonist Full agonist 7.7 pKi - 2
pKi 7.7 [2]
β3-adrenoceptor Rn Agonist Full agonist 7.7 pKi - 2
pKi 7.7 [2]
Ligand mentioned in the following text fields