cabozantinib

Ligand id: 5887

Name: cabozantinib

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: cabozantinib

Structure and Physico-chemical Properties

2D Structure
Click here for structure editor
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 10
Topological polar surface area 98.78
Molecular weight 501.17
XLogP 4.58
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Abou-Alfa GK, Meyer T, Cheng AL, El-Khoueiry AB, Rimassa L, Ryoo BY, Cicin I, Merle P, Chen Y, Park JW et al.. (2018)
Cabozantinib in Patients with Advanced and Progressing Hepatocellular Carcinoma.
N. Engl. J. Med., 379 (1): 54-63. [PMID:29972759]
2. Choueiri TK, Escudier B, Powles T, Mainwaring PN, Rini BI, Donskov F, Hammers H, Hutson TE, Lee JL, Peltola K et al.. (2015)
Cabozantinib versus Everolimus in Advanced Renal-Cell Carcinoma.
N. Engl. J. Med., 373 (19): 1814-23. [PMID:26406150]
3. FDA. 
FDA approves cabozantinib for hepatocellular carcinoma.
Accessed on 16/01/2019. Modified on 16/01/2019. www.fda.gov, https://www.fda.gov/Drugs/InformationOnDrugs/ApprovedDrugs/ucm629512.htm?utm_campaign=Oncology%201%2F15%2F2019%20cabozantinib&utm_medium=email&utm_source=Eloqua&elqTrackId=f0cd47cbe0e04a7e88308645f7d66a61&elq=249a34ffaff94fdb97f2d843ed80fa79&elqaid=6487&elqat=1&elqCampaignId=5289
4. FDA. 
FDA grants regular approval to Cabometyx for first-line treatment of advanced renal cell carcinoma.
Accessed on 03/01/2018. Modified on 03/01/2018. fda.gov, https://www.fda.gov/Drugs/InformationOnDrugs/ApprovedDrugs/ucm589842.htm?utm_campaign=Oncology%2012%2F20&utm_medium=email&utm_source=Eloqua&elqTrackId=9bc32150b77e4929b686ed8a82ffbb6e&elq=70477587f45543ad83873a1367bab364&elqaid=1850&elqat=1&elqCampaignId=1227
5. Subbiah V, Gainor JF, Rahal R, Brubaker JD, Kim JL, Maynard M, Hu W, Cao Q, Sheets MP, Wilson D et al.. (2018)
Precision Targeted Therapy with BLU-667 for RET-Driven Cancers.
Cancer Discov, 8 (7): 836-849. [PMID:29657135]
6. Yakes FM, Chen J, Tan J, Yamaguchi K, Shi Y, Yu P, Qian F, Chu F, Bentzien F, Cancilla B et al.. (2011)
Cabozantinib (XL184), a novel MET and VEGFR2 inhibitor, simultaneously suppresses metastasis, angiogenesis, and tumor growth.
Mol. Cancer Ther., 10 (12): 2298-308. [PMID:21926191]