cabozantinib

Ligand id: 5887

Name: cabozantinib

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Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 10
Topological polar surface area 98.78
Molecular weight 501.17
XLogP 4.58
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
kinase insert domain receptor Hs Inhibitor Inhibition 10.5 pIC50 - 6
pIC50 10.5 (IC50 3.5x10-11 M) [6]
MET proto-oncogene, receptor tyrosine kinase Hs Inhibitor Inhibition 8.9 pIC50 - 6
pIC50 8.9 (IC50 1.3x10-9 M) [6]
ret proto-oncogene Hs Inhibitor Inhibition 8.0 pIC50 - 5
pIC50 8.0 (IC50 1.1x10-8 M) [5]
Description: In a biochemical assay.