Synonyms: 1-naphthyl PP1 | AC1NP9I6 | mutant kinases inhibitor II | NM-PP1
Compound class:
Synthetic organic
Comment: This compound is a potent inhibitor of several mutant kinase enzymes [3]. Also inhibits Src family kinases and c-Abl.
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References |
1. Anastassiadis T, Deacon SW, Devarajan K, Ma H, Peterson JR. (2011)
Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity. Nat Biotechnol, 29 (11): 1039-45. [PMID:22037377] |
2. Gao Y, Davies SP, Augustin M, Woodward A, Patel UA, Kovelman R, Harvey KJ. (2013)
A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery. Biochem J, 451 (2): 313-28. [PMID:23398362] |
3. Saghatelian A, Cravatt BF. (2005)
Assignment of protein function in the postgenomic era. Nat Chem Biol, 1 (3): 130-42. [PMID:16408016] |