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Synonyms: ISP-1 | thermozymocidin
Compound class: Synthetic organic
Comment: Myriocin is a sphingosine-like potent immunosuppressant acting primarily via inhibition of serine palmitoyltransferase which catalyses the first step of sphingolipid biosynthesis . The compound was originally isolated from the fungus Isaria sinclarii.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Miyake Y, Kozutsumi Y, Nakamura S, Fujita T, Kawasaki T. (1995)
Serine palmitoyltransferase is the primary target of a sphingosine-like immunosuppressant, ISP-1/myriocin.
Biochem Biophys Res Commun, 211 (2): 396-403. [PMID:7794249]