azilsartan   Click here for help

GtoPdb Ligand ID: 6901

Synonyms: TAK 536 | TAK-536 | TAK536
Compound class: Synthetic organic
Comment: The active form of the approved drug azilsartan medoxomil.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 7
Topological polar surface area 123.24
Molecular weight 456.14
XLogP 5.7
No. Lipinski's rules broken 1
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Canonical SMILES CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]oc(=O)n1)c(ccc2)C(=O)O
Isomeric SMILES CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]oc(=O)n1)c(ccc2)C(=O)O
InChI InChI=1S/C25H20N4O5/c1-2-33-24-26-20-9-5-8-19(23(30)31)21(20)29(24)14-15-10-12-16(13-11-15)17-6-3-4-7-18(17)22-27-25(32)34-28-22/h3-13H,2,14H2,1H3,(H,30,31)(H,27,28,32)
1. Rakugi H, Nakata E, Sasaki E, Kagawa T. (2014)
Evaluation of the efficacy and tolerability of fixed-dose combination therapy of azilsartan and amlodipine besylate in Japanese patients with grade I to II essential hypertension.
Clin Ther, 36 (5): 711-21. [PMID:24742498]
2. Takahara M, Shiraiwa T, Shindo M, Arai A, Kusuda Y, Katakami N, Kaneto H, Matsuoka TA, Shimomura I. (2014)
Efficacy and safety of 10-mg azilsartan compared with 8-mg candesartan cilexetil in Japanese patients with hypertension: a randomized crossover non-inferiority trial.
Hypertens Res, 37 (9): 852-7. [PMID:24739538]