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tolazoline is an approved drug (FDA (1948))
Compound class: Synthetic organic
Comment: Tolazoline is a non-selective α-adrenoceptor antagonist.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Jasper JR, Lesnick JD, Chang LK, Yamanishi SS, Chang TK, Hsu SA, Daunt DA, Bonhaus DW, Eglen RM. (1998)
Ligand efficacy and potency at recombinant alpha2 adrenergic receptors: agonist-mediated [35S]GTPgammaS binding.
Biochem. Pharmacol., 55 (7): 1035-43. [PMID:9605427]
2. Teskin O, Uydeş-Dogan BS, Enç Y, Alp FI, Kaleli D, Keser S, Iyigün T, Bilgen F, Dagsali S, Ozdemir O. (2006)
Comparative effects of tolazoline and nitroprusside on human isolated radial artery.
Ann. Thorac. Surg., 81 (1): 125-31. [PMID:16368348]