Synonyms: AMR-101 | icosapent ethyl | icosapentate | Vascepa® | Vazkepa®
icosapent is an approved drug (FDA (2012), EMA (2021))
Compound class:
Synthetic organic
Comment: Icosapent is a synthetic ethyl ester derivative of the omega-3 fatty acid eicosapentaenoic acid (EPA). It is de-esterified during absorption to active EPA that is absorbed in the small intestine.
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References |
1. Ballantyne CM, Braeckman RA, Soni PN. (2013)
Icosapent ethyl for the treatment of hypertriglyceridemia. Expert Opin Pharmacother, 14 (10): 1409-16. [PMID:23701295] |
2. Bays HE, Braeckman RA, Ballantyne CM, Kastelein JJ, Otvos JD, Stirtan WG, Soni PN. (2012)
Icosapent ethyl, a pure EPA omega-3 fatty acid: effects on lipoprotein particle concentration and size in patients with very high triglyceride levels (the MARINE study). J Clin Lipidol, 6 (6): 565-72. [PMID:23312052] |