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Synonyms: AHR-504 | Qbrexza® (glycopyrronium cloth) | Robinul® | Seebri Neohaler® | Tovanor Breezhaler®
glycopyrrolate is an approved drug (FDA (1961), EMA (2012))
Compound class: Synthetic organic
Comment: Glycopyrrolate is the active moiety of the approved drug glycopyrronium bromide. It is an anticholinergic drug.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
View more information in the IUPHAR Pharmacology Education Project: glycopyrronium
1. Hansel TT, Neighbour H, Erin EM, Tan AJ, Tennant RC, Maus JG, Barnes PJ. (2005)
Glycopyrrolate causes prolonged bronchoprotection and bronchodilatation in patients with asthma.
Chest, 128 (4): 1974-9. [PMID:16236844]
2. Stocks MJ, Alcaraz L, Bailey A, Bowers K, Donald D, Edwards H, Hunt F, Kindon N, Pairaudeau G, Theaker J et al.. (2010)
The discovery of new spirocyclic muscarinic M3 antagonists.
Bioorg Med Chem Lett, 20 (24): 7458-61. [PMID:21036043]
3. Sykes DA, Dowling MR, Leighton-Davies J, Kent TC, Fawcett L, Renard E, Trifilieff A, Charlton SJ. (2012)
The Influence of receptor kinetics on the onset and duration of action and the therapeutic index of NVA237 and tiotropium.
J Pharmacol Exp Ther, 343 (2): 520-8. [PMID:22854200]
4. Tzelepis G, Komanapolli S, Tyler D, Vega D, Fulambarker A. (1996)
Comparison of nebulized glycopyrrolate and metaproterenol in chronic obstructive pulmonary disease.
Eur Respir J, 9 (1): 100-3. [PMID:8834341]