Ligand id: 7472

Name: lacosamide

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View more information in the IUPHAR Pharmacology Education Project: lacosamide

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 8
Topological polar surface area 67.43
Molecular weight 250.13
XLogP 0.51
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

1. Abdelsayed M, Sokolov S, Ruben PC. (2013)
A thermosensitive mutation alters the effects of lacosamide on slow inactivation in neuronal voltage-gated sodium channels, NaV1.2.
Front Pharmacol, 4: 121. [PMID:24065921]
2. Beyreuther BK, Freitag J, Heers C, Krebsfänger N, Scharfenecker U, Stöhr T. (2007)
Lacosamide: a review of preclinical properties.
CNS Drug Rev, 13 (1): 21-42. [PMID:17461888]
3. Sheets PL, Heers C, Stoehr T, Cummins TR. (2008)
Differential block of sensory neuronal voltage-gated sodium channels by lacosamide [(2R)-2-(acetylamino)-N-benzyl-3-methoxypropanamide], lidocaine, and carbamazepine.
J. Pharmacol. Exp. Ther., 326 (1): 89-99. [PMID:18378801]