lacosamide   Click here for help

GtoPdb Ligand ID: 7472

Synonyms: ADD 234037 | erlosamide | harkeroside | SPM 927 | Vimpat®
Approved drug
lacosamide is an approved drug (EMA and FDA (2008))
Compound class: Synthetic organic
Comment: Lacosamide is a functionalized amino acid anticonvulsant drug [2].
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 8
Topological polar surface area 67.43
Molecular weight 250.13
XLogP 0.51
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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Canonical SMILES COCC(C(=O)NCc1ccccc1)NC(=O)C
Isomeric SMILES COC[C@H](C(=O)NCc1ccccc1)NC(=O)C
InChI InChI=1S/C13H18N2O3/c1-10(16)15-12(9-18-2)13(17)14-8-11-6-4-3-5-7-11/h3-7,12H,8-9H2,1-2H3,(H,14,17)(H,15,16)/t12-/m1/s1
InChI Key VPPJLAIAVCUEMN-GFCCVEGCSA-N
Bioactivity Comments
We have tagged the Nav1.7 voltage-gated sodium channel as the primary target of this drug, simply as this is the only human voltage-gated sodium channel for which we have been able to find affinity data. This does not preclude interaction at other sodium channels.
Selectivity at ion channels
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
Nav1.8 Rn Channel blocker Antagonist 4.8 pIC50 - 3
pIC50 4.8 (IC50 1.6x10-5 M) [3]
Nav1.2 Rn Channel blocker Antagonist 4.5 pIC50 - 1
pIC50 4.5 (IC50 3x10-5 M) [1]
Voltage: -80.0 mV
Nav1.7 Primary target of this compound Hs Channel blocker Antagonist 3.7 pIC50 - 3
pIC50 3.7 (IC50 1.82x10-4 M) [3]
Nav1.3 Rn Channel blocker Antagonist 3.4 pIC50 - 3
pIC50 3.4 (IC50 4.15x10-4 M) [3]