Ligand id: 7472

Name: lacosamide

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Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 8
Topological polar surface area 67.43
Molecular weight 250.13
XLogP 0.51
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
We have tagged the Nav1.7 voltage-gated sodium channel as the primary target of this drug, simply as this is the only human voltage-gated sodium channel for which we have been able to find affinity data. This does not preclude interaction at other sodium channels.
Selectivity at ion channels
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
Nav1.8 Rn Channel blocker Antagonist 4.8 pIC50 - 3
pIC50 4.8 (IC50 1.6x10-5 M) [3]
Nav1.2 Rn Channel blocker Antagonist 4.5 pIC50 - 1
pIC50 4.5 (IC50 3x10-5 M) [1]
Voltage: -80.0 mV
Nav1.7 Hs Channel blocker Antagonist 3.7 pIC50 - 3
pIC50 3.7 (IC50 1.82x10-4 M) [3]
Nav1.3 Rn Channel blocker Antagonist 3.4 pIC50 - 3
pIC50 3.4 (IC50 4.15x10-4 M) [3]