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Synonyms: β/ω-theraphotoxin-Tp2a | β/ω-TRTX-Tp2a | protoxin-2 | ProTx-2 | ProTx-II | ProTx2 | PT-II
Compound class:
Peptide or derivative
Comment: Toxin from Thrixopelma pruriens (Peruvian green velvet tarantula).
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
| References |
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1. Middleton RE, Warren VA, Kraus RL, Hwang JC, Liu CJ, Dai G, Brochu RM, Kohler MG, Gao YD, Garsky VM et al.. (2002)
Two tarantula peptides inhibit activation of multiple sodium channels. Biochemistry, 41 (50): 14734-47. [PMID:12475222] |
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2. Schmalhofer WA, Calhoun J, Burrows R, Bailey T, Kohler MG, Weinglass AB, Kaczorowski GJ, Garcia ML, Koltzenburg M, Priest BT. (2008)
ProTx-II, a selective inhibitor of NaV1.7 sodium channels, blocks action potential propagation in nociceptors. Mol Pharmacol, 74 (5): 1476-84. [PMID:18728100] |
