protoxin II   Click here for help

GtoPdb Ligand ID: 7571

Synonyms: β/ω-theraphotoxin-Tp2a | β/ω-TRTX-Tp2a | protoxin-2 | ProTx-2 | ProTx-II | ProTx2 | PT-II
Comment: Toxin from Thrixopelma pruriens (Peruvian green velvet tarantula).
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Selectivity at ion channels
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
Nav1.2 Hs Gating inhibitor Voltage-dependent inhibition 7.4 pKi - 2
pKi 7.4 [2]
Voltage: -100.0 mV
Description: Whole cell voltage clamp of transfected human embryonic kidney cells (HEK293)
Conditions: Holding potential of -100 mV, approximatley the voltage for half-maximal inactivation
Nav1.5 Hs Gating inhibitor Voltage-dependent inhibition 6.5 pKi - 1
pKi 6.5 [1]
Voltage: -80.0 mV
Description: Whole-cell voltage clamp of human Nav1.5 channels expressed in human embryonic kidney cells (HEK293).
Conditions: Holding potential of -80 mV.