Synonyms: Ivemend® | MK-0517
fosaprepitant is an approved drug (FDA and EMA (2008))
Compound class:
Synthetic organic
Comment: Marketed formulations contain fosaprepitant dimeglumine.
![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖![]() View more information in the IUPHAR Pharmacology Education Project: fosaprepitant |
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References |
1. Hale JJ, Mills SG, MacCoss M, Dorn CP, Finke PE, Budhu RJ, Reamer RA, Huskey SE, Luffer-Atlas D, Dean BJ et al.. (2000)
Phosphorylated morpholine acetal human neurokinin-1 receptor antagonists as water-soluble prodrugs. J Med Chem, 43 (6): 1234-41. [PMID:10737756] |
2. Hornby PJ. (2001)
Central neurocircuitry associated with emesis. Am J Med, 111 Suppl 8A: 106S-112S. [PMID:11749934] |