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Compound class: Synthetic organic
Comment: This compound is a specific cathepsin K inhibitor  (compound 22 in the article), which is used as a functional probe in studying the effects of cathepsin K inhibition.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Desmarais S, Massé F, Percival MD. (2009)
Pharmacological inhibitors to identify roles of cathepsin K in cell-based studies: a comparison of available tools.
Biol Chem, 390 (9): 941-8. [PMID:19453281]
2. Grabowskal U, Chambers TJ, Shiroo M. (2005)
Recent developments in cathepsin K inhibitor design.
Curr Opin Drug Discov Devel, 8 (5): 619-30. [PMID:16159024]
3. Li CS, Deschenes D, Desmarais S, Falgueyret JP, Gauthier JY, Kimmel DB, Léger S, Massé F, McGrath ME, McKay DJ et al.. (2006)
Identification of a potent and selective non-basic cathepsin K inhibitor.
Bioorg Med Chem Lett, 16 (7): 1985-9. [PMID:16413777]
4. Stroup GB, Lark MW, Veber DF, Bhattacharyya A, Blake S, Dare LC, Erhard KF, Hoffman SJ, James IE, Marquis RW et al.. (2001)
Potent and selective inhibition of human cathepsin K leads to inhibition of bone resorption in vivo in a nonhuman primate.
J Bone Miner Res, 16 (10): 1739-46. [PMID:11585335]